Monday, January 30, 2012

Willpower and desires: Turning up the volume on what you want most

ScienceDaily (Jan. 30, 2012) ? Trying to resist that late-night tweet or checking your work email again? The bad news is that desires for work and entertainment often win out in the daily struggle for self-control, according to a new study that measures various desires and their regulation in daily life.

"Modern life is a welter of assorted desires marked by frequent conflict and resistance, the latter with uneven success," says Wilhelm Hofmann of the University of Chicago Booth School of Business. Determining how to best resist desires is not as easy as it seems, according to personality and social psychologists who recently presented new research in San Diego about willpower and food psychology.

Resisting desires

In the new study of desire regulation, 205 adults wore devices that recorded a total of 7,827 reports about their daily desires. Desires for sleep and sex were the strongest, while desires for media and work proved the hardest to resist. Even though tobacco and alcohol are thought of as addictive, desires associated with them were the weakest, according to the study. Surprisingly to the researchers, sleep and leisure were the most problematic desires, suggesting "pervasive tension between natural inclinations to rest and relax and the multitude of work and other obligations," says Hofmann, the lead author of the study forthcoming in Psychological Science.

Moreover, the study supported past research that the more frequently and recently people have resisted a desire, the less successful they will be at resisting any subsequent desire. Therefore as a day wears on, willpower becomes lower and self-control efforts are more likely to fail, says Hofmann, who co-authored the paper with Roy Baumeister of Florida State University and Kathleen Vohs of the University of Minnesota.

Scientists who study the complex interplay between desires and self control say that passing up on temptation is made ever more difficult by the idea that there is no single or clear feeling that alerts us to when our willpower is low. "But we find that when willpower is low, everything is felt more intensely," says Baumeister, author of Willpower: Rediscovering the Greatest Human Strength. "Low willpower seems to turn up the volume on life."

In a series of experiments, Baumeister and his colleagues found that people with low willpower reported more distress in response to an upsetting film and rated cold water as more painful during a cold-water immersion test. They also had stronger desires to open a gift and to keep eating cookies.

Postponing a snack

The effects of willpower depletion explain why so many people have trouble resisting unhealthy food -- the more they resist the food, the more they crave it. That's why one group of researchers is looking at ways people can alter their physical cravings. Nicole Mead of Catolica-Lisbon School of Business and Economics and her colleagues tested the notion that postponing consumption of a unhealthy snack to an unspecified future time would reduce the desire for, and therefore consumption of, that snack.

In one experiment, Mead's team gave 105 high school students in the Netherlands a bag of potato chips. Some participants received instructions to either postpone, restrain, or consume the potato chips, while others could choose among the three eating strategies. Over the course of one week, students who initially postponed eating the chips subsequently ate the least amount of the chips, regardless of whether they chose or were given the strategy. They ate even more than those who were instructed to not eat them at all.

"Postponing consumption is an effective strategy that consumers can use for controlling unwanted food-related desires," Mead says. "In modern society, people are absolutely inundated with opportunities to consume, and this strategy may be particularly helpful because it primarily works through desire reduction rather than willpower enhancement." Future research will examine whether the strategy works for other transient impulses, such as spending and sexual desires.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/67VHqqfqAWQ/120130094353.htm

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Sunday, January 29, 2012

Academy makes credits exception for 'Tree of Life' (omg!)

LOS ANGELES, Jan 27 (TheWrap.com) - The Academy has made an unusual exception for "The Tree of Life," determining that the film has four true producers and should not be limited by an AMPAS rule that limits the number of producers on a Best Picture nominee to three.

Sarah Green, Bill Pohlad, Dede Gardner and Grant Hill all "functioned as genuine producers" on the Terrence Malick film, according to a ruling from the Academy's Producers Branch Executive Committee. Under Academy rules that went into effect after five producers won Oscar statuettes for "Shakespeare in Love" in 1999, more than three producers can be credited only in the case of a "rare and extraordinary circumstance."

Typically, the Academy allows the Producers Guild of America to determine which producers truly deserve credit. "The Tree of Life" did not receive a PGA nomination.

Of the other eight Best Picture nominees, "The Descendants," "The Help" and "Moneyball" have three credited producers; "Hugo," "Midnight in Paris" and "War Horse" have two; and "The Artist" and "Extremely Loud & Incredibly Close" have one.

Last year, the Academy made an exception for "The Social Network," which earned Oscar nominations for four of its producers. The previous year they did the same for Best Picture winner "The Hurt Locker."

The producer who most likely would have been eliminated if AMPAS had enforced the three-producer limit in that case was Nicolas Chartier, who was later banned from the Oscar show for emails disparaging "Avatar."

(Editing By Zorianna Kit)

Source: http://us.rd.yahoo.com/dailynews/rss/entertainment/*http%3A//us.rd.yahoo.com/dailynews/external/omg_rss/rss_omg_en/news_academy_makes_credits_exception_tree_life020404313/44334056/*http%3A//omg.yahoo.com/news/academy-makes-credits-exception-tree-life-020404313.html

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Saturday, January 28, 2012

Iolo System Mechanic 10.7


If sluggish PC performance is giving you the blues, you'd do well to invest in the $39.95 Iolo System Mechanic 10.7, a utility suite?designed to blow the virtual dust out of worn machines by repairing the registry, defragging the hard drive, and eliminating files that stymie snappy performance. Iolo System Mechanic 10.7 serves up a host of new features not present in previous builds we've reviewed, including Designated Drivers which manages drivers in an attempt to keep your PC problem free. All in all, Iolo System Mechanic remains one of the best PC tune-up utilities around, as it digs deep, cleans up PCs well, and offers informative, easy-to-understand help about the problems that plague computers.

System Requirements and Interface
Compatible with Windows 7, Vista, and XP PCs, Iolo System Mechanics 10 requires just 30MB of disk space, 256MB of RAM, and an Internet connection for activating the license.?Unlike most PC tune-up utilities such as TuneUp Utilities 2012 (4 stars, $49.95), which limit you on the number of licenses, Iolo System Mechanic 10.7 lets you install the software on any number of computers provided that it's not for business purposes?a welcome feature in the age of the multi-PC household.

The interface looks very similar to previous entries in the Iolo System Mechanic family with the familiar red-white-and-blue color scheme. Like the previous version of System Mechanic, this version has several options in the left pane (Overview, Problems, Automated Tasks, Anti-malware, Firewall, All-in-One Tools, Individual Tools) the content of which appears in the main pane when clicked.

Iolo System Mechanic 10.7 also installs a useful widget on the desktop that gives you at-a-glance PC health and security readings. From this widget, you can launch any number of Iolo System Mechanic 10.7's features to begin the clean up process.

The Clean Up Process
The Overview screen opens by default when the program is launched, and it's where the "Analyze Now" button lives. Clicking the arrow next to it opened drop-down box that presented two choices: "Perform Quick Analysis" and "Perform Deep Analysis." The former is a one- to two-minute scan that looks for the most common PC problems; the latter is a five- to seven-minute scan that checks for all problems. Considering the heavy use that our test laptop had received, I went with the second option. Approximately six minutes later finished the scan and uncovered over 2,000 problems.

Beneath the reading appeared a highlighted message: "Boost speed and stability by removing redundant programs with CRUDD Remover." CRUDD is Iolo's acronym for Commonly Redundant or Unnecessary Decelerators and Destabilizers?fancy talk for duplicate programs that clog your system. The idea behind CRUDD Remover is to eliminate those extra programs as each application install theoretically slows your PC's performance a bit. After running CRUDD Remover, 9 problems were detected on the PC, which were explained in wonderful detail on the "Problems" screen.

What I found truly cool was that Iolo System Mechanic 10 didn't just serve up a number?it provided blurbs that explained why these problems negatively impact performance. I checked off all nine problems, clicked the "Repair All" button, and performed the required reboot. Performing another deep scan revealed that all but one problem was fixed, and that straggler was one beyond Iolo System Mechanic 10.7's scope: No installed anti-malware program was detected on the system.

I also ran Iolo's patent-pending Program Accelerator, which smartly re-aligns all of a program's dependent files on the hard drive. It's touted as being better than disk defragmenters, which can blindly compact and separate files even more. Program Accelerator took approximately 15 minutes for to work its magic, and, when it was done, I discovered that it had re-aligned over 30,000 files and eliminated nearly 100 file fragments. Four further files were defragmented after a restart.

Performance Improvements
I tested Iolo System Mechanic 10.7's ability to whip a PC back into shape by performing three tests?running the Geekbench system performance tool, measuring boot times, and transferring a 1.1GB folder of mixed media to external storage?before and after running the software to compare the computer's potency. Each test was run three times and averaged. Before AVG PC Tuneup 2011 scrubbed the system, the 2-GHz Intel Core i7 X990 Style-Note notebook with 4GB of RAM, and an 80GB Intel SSD drive achieved a 5,903 Geekbench score, booted in 50.3 seconds, and transferred the 1.1GB folder in 40.5 seconds.

After using Iolo System Mechanic 10.7, the system saw the most improved performance of all the tune-up utilities tested: The GeekBench score rose to 6064 (better than TuneUp Utilities 2012's 6045); the boot time decreased to just 37.1 seconds (on a par with TuneUp Utilities 2012's 37 seconds). The file transfer speed dropped to 40.8 seconds (swifter than TuneUp Utilities 2012's 41.1 seconds).?The overall system performance was incredibly fast and snappy?windows and menus opened in a blink.

Designated Drivers and NetBooster
Designated Drivers, a new feature to version 10.7, helps you find and install safe drivers for your computer?drivers that have been tested and certified by Microsoft. I liked that this driver utility is a part of Iolo System Mechanic 10.7 and not a separate application (which is the case with SlimWare Utilities SlimCleaner and SlimWare Utilities DiverUpdate). Designated Drivers found two driver updates for my PC, but Slimware Utilities DriverUpdate found a whopping 74.

The NetBooster internet booster is designed to stabilize and speed up your internet connection by optimizing settings?Iolo states that it's beneficial to run it before playing Web-connected video games and assists in opening Web pages faster. Cracked.com loaded in 5.9 seconds before running NetBooster, which decreased slightly (after clearing the browser's Internet history, rebooting, and activating the tool) to 5.3 seconds?a marginal increase.

Should You Use Iolo System Mechanic 10.7?
The answer is a resounding yes. Iolo System Mechanic 10.7 has simple interface, easy-to-understand problem definitions, and a deep array of performance-enhancing tools that produce excellent all-around scores. Iolo System Mechanic remains the PC tune-up-utility champion.

More Utility Suites Reviews:
??? Iolo System Mechanic 10.7
??? Diskeeper 2011 Professional
??? Avanquest Fix-It Utilities 11 Professional
??? Norton Utilities
??? AVG PC Tuneup 2011
?? more

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/w-7L2zSR7ZE/0,2817,2371043,00.asp

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97% The Artist

"With pleasure!"Hollywood, 1927: As silent movie star George Valentin wonders if the arrival of talking pictures will cause him to fade into oblivion, he sparks with Peppy Miller, a young dancer set for a big break. REVIEWThis light-footed and warm-hearted souffl? of a movie is a reminder of just how much fun it can be to go to the movies. A film about a silent film star struggling with the transition to talkies that is itself a silent film is the kind of cutesy high concept premise that could go down in flames in the hands of the wrong team. But writer/director Michel Hazanivicius and his stars, Jean Dujardin and Berenice Bejo, know exactly how to sell the material so that it all works beautifully. What I liked most about the movie is that it doesn't spend all of its time winking to itself for its own cleverness, as you might expect it would. It doesn't use its silent film conventions to make any kind of commentary on silent films. Hazanivicius and company wanted to make a silent film because they thought it was the best way to tell this particular story, and that's just what they've done, without apologies.Dujardin and Bejo are being lauded for their performances, and rightly so. It would be easy to dismiss their work as being unchallenging, but I have a feeling both had more difficult roles than one might first assume, and that the fact that they both make it look so easy is part of why they're so good. And the movie looks stunning -- one of the benefits of it being silent is that with words removed from the equation, the images take on extra responsibility to communicate the movie's ideas to us, and what cinephile could resist anything that makes a film more cinematic? Captured with brilliant production design by Laurence Bennett and gorgeously shot by Guillaume Schiffman in scintillating black and white evoking the silent era to perfection. Glamorous and hear-felt with genuine pathos and peppered with enough knowing laughs (thanks largely to Uggie The Dog as Valentin's constant companion) the film is a masterpiece about movie-making and the magic of the movies. One of the year's best and a must see for cinemaniacs!

January 26, 2012

Source: http://www.rottentomatoes.com/m/the_artist/

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Friday, January 27, 2012

'Toddlers' mom sues media for sexualizing girl

Marc Andrew Deley / Getty Images

Isabella Barrett at the "Toddlers and Tiaras" Reality Weekly Launch Event benefiting her anti-bullying bracelets on Dec. 29 in Providence, R.I.

By Anna Chan

She's not sexy and she doesn't know it!

That's what "Toddlers & Tiaras" pageant mom Susanna Barrett insists about her 5-year-old glam princess Isabella. Barrett claims that after a video of her little girl singing LMFAO's "I'm Sexy and I Know It" at a night spot?surfaced, several media outlets tried to turn the non-sexual performance into something inappropriate, and she's suing mad.

According to the New York Daily News, Barrett filed a $30 million libel lawsuit on?Tuesday in Manhattan. She claims that TMZ, The Huffington Post and the Daily Mail described the little girl's act? as "gyrating in a nightclub and singing about her sex appeal" when in fact Isabella was sitting during the song.

"(Isabella) did not understand the concept of sex, let alone 'sex appeal' and could not have been singing about her own sex appeal," Barrett said in her lawsuit. Instead, "it is the defendants who, through their articles, have thrust these false and vulgar characteristics on to Isabella," according to the suit.?"As a result, Isabella is now perceived sexually, erotically and pornographically, and (the stories) have placed Isabella in serious physical danger, attracting the attention of others who would seek to sexualize a child."

Not long after the video surfaced, Barrett defended Isabella's videotaped performance to TMZ. She explained that the little girl was at New York's Libation for a pet charity event and started singing when the DJ invited her up, but that they left at the reasonable hour of 9 p.m.

As for how the 5-year-old knows the lyrics to the LMFAO tune? "We just listen to the radio, and that's a real catchy song," she told TMZ at the time.

Do you agree with Susanna that it's the websites' fault for sexualizing Isabella's performance? Tell us what you think on our Facebook page.

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Source: http://theclicker.today.msnbc.msn.com/_news/2012/01/26/10245633-toddlers-mom-sues-media-for-sexualizing-daughter

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Just Show Me: How to clear your browser history in Safari (Yahoo! News)

Welcome to?Just Show Me on?Tecca TV, where we show you tips and tricks for getting the most out of the?gadgets in your life. In today's episode we'll show you how to clear your history in the?Safari web browser.

Clearing your history is a good idea if you're ever on a public computer or use a system that could be viewed by someone else. Your browser history tells people a lot, perhaps more then you'd like them to know! Clearing it is easy, and we'll walk you through the steps in our video.

Take a look at these other episodes of Just Show Me that'll help you use your Safari web browser to the full potential:

For even more episodes of Just Show Me,?subscribe to Tecca TV's YouTube channel and?check out all our Just Show Me episodes. If you have any topics you'd like to see us cover, just drop us a line in the comments.

This article originally appeared on Tecca

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Source: http://us.rd.yahoo.com/dailynews/rss/personaltech/*http%3A//news.yahoo.com/s/yblog_technews/20120127/tc_yblog_technews/just-show-me-how-to-clear-your-browser-history-in-safari

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Thursday, January 26, 2012

Do the Oscars Hate People Having Sex?

Reel Sex

People were up in arms Tuesday after the announcement of nominees for the 84th Annual Academy Awards. So many seem to forget that every year they are disappointed with the nominees and every year there is some film or performer who was left off or included on the prestigious list. I may have spent the final weeks of 2011 lamenting my utter ennui with last year?s films, but I never in a million years expected some of the Oscar outcomes. No Supporting Actor nomination for Albert Brooks, whose performance in Drive unnerved audiences to the core? Or the blatant disregard for solid documentary filmmaking in The Interrupters, Buck, or Project Nim, three entries into filmmaking that will forever impact the way we view the world around us? No, the Academy seemed to forget the impressive and daring offerings in favor of an adorable dog in a silent film. What is this, 1920? Last I checked The Jazz Singer pushed us into the land of the talkies.

I could spend all day gnawing my tongue over which films shouldn?t have been included in this year?s awards recognition, but just like arguing the virtues and evils of the MPAA, our time is better used talking about some of the sexy pieces of work that the Academy felt were too provocative to include (for reasons I have completely made up in my mind. Hey, they have their prerogative, I have mine.). Going along with the Academy?s new voodoo math rules of deciding the appropriate number of Best Picture nominees (something about getting 5% votes and then jumping a broom after falling off a cliff), I have picked out nine salacious films ignored for what we can only assume is their brave use of sex, sexual orientation, Ezra Miller?s hips, or worldwide punishment for one woman?s ill-timed infidelity.

As The Rock so eloquently asked for in the cinematic masterpiece Fast Five, let?s start with the veggies. The veggies in this case are the less obvious and therefore easily forgotten entries. Dee Rees?s Pariah is one of those incredibly simple yet thought provoking films the Academy loves to ignore. They see ?black,? ?lesbian,? and ?inner city? in the summary and instantly the monocle-wearing older gentlemen running ?things? mutter to themselves ?well, who would want to watch that type of film? Didn?t we already try being edgy with Precious?? Well, it turns out the Sundance darling is actually an engaging and inspiring piece of film that focuses just as much on lead character Alike?s (Adepero Oduye) sexual awakening and as it does on her acceptance of self. She is a prime example of a character moving forward from the heartbreak of a sexual coming-of-age, and Rees?s perfectly sculpted script would have been a shining beacon amongst the worn out drivel (Bridesmaids aside) competing for Best Original Screenplay.

Another daring and controversial film ignored in the Best Original Screenplay category is the tight, brutal, and sexually-charged Bellflower. Now, I know suggesting rookie Evan Glodell?s story of what happens when love goes wrong may seem a little out there (remember, we Rejects are champions of all things Medusa), I want to point out that the script is one of the more surprisingly realistic offerings of 2011. Last year was full of films uncovering the darker, sadder parts of love, and Bellflower was courageous enough to compare the destruction of love to the terror of the Apocalypse?but with sexier people. Fortunately we will see more from both Rees and Glodell in the future, but it?s a pity these two sexually daring scripts won?t get the same stamp of approval as the nearly silent The Artist.

I know you might be ready to jump down to read (again) about Michael Fassbender?s boner in Shame, and I promise you I haven?t forgotten about him, but before we do that let?s talk about a film genre near and dear to my heart?documentaries. Director Errol Morris released the hilarious and unnerving documentary Tabloid last summer, a film chronicling the sexual delusions of a woman who would eventually become one of the most notorious subjects of tabloid fodder. What Tabloid introduces, besides a crazy woman, is the well-accepted notion that a woman cannot rape a man. This may have not been Morris?s intended theme, however it is one that is blatantly clear once the story of former Miss Wyoming Joyce McKinney?s obsession and abduction of her Mormon boyfriend begins to reveal that she forced herself upon him while keeping him against his will.

McKinney recounts the story for Morris, who does not shy away from the satire the subject lends herself, and in each passing scene her sanity is questioned along with the audience?s understanding of what constitutes rape. Unlike the narrative The Girl With the Dragon Tattoo, rape in Tabloid almost comes off like a joke. As if it is something only humor can remedy. And regardless of how sensitive the subject, the lighter touching of rape in this documentary actually proves that McKinney is a nut job. This year?s Best Documentary nominees cannot hold a candle to the inspiring filmmaking Morris is capable of doing even when he?s not trying to make a serious film.

Infidelity, like rape, is something the Academy enjoys primarily seeing when the victim is being punished for being just that, a victim. Steven Soderbergh?s Contagion absolutely deserves no accolades for its uneven portrayal of a world-wide epidemic, however composer wunderkind Cliff Martinez does deserve a nod for beautifully narrating the nearly world-ending catastrophe brought on by one woman?s ill planned affair. Along with Alberto Iglesias?s moving score for Tinker Tailor Solider Spy (thankfully sitting high on the nomination hog), Martinez?s Contagion score perfectly captures the foreboding feeling the ensemble cast feels as their story unfolds. Without the use of a slutty trumpet or a saucy drum roll, Martinez hinted unobtrusively to the dire consequences infidelity can have on more than just the two parties involved, even if we really should be blaming the bat-pig.

Our last five rudely neglected films feature performances audiences will remember well beyond some of their would-have-been competitors. Don?t worry; I?m not putting the shirtless Channing Tatum into this bunch. Starting with the Best Supporting Actor category, two sexually daring (confusing?) performances were forgotten. First was the sexy-creepy Patrick (John Hawkes) in Martha Marcy May Marlene, a man so sexually compelling he had an entire cult of lost Urban Outfitter models following him along on morally conflicting excursions. Hawkes is quickly becoming the Judy Greer of the indie scene, and the Academy?s exclusion of him in the Best Supporting Actor category once again proves they just don?t get it (and maybe they need to get some).

Meanwhile, another scene-stealing background performer whose name was not called yesterday was Patton Oswalt. Young Adult was entirely forgotten this year, and it is an insult that Oswalt?s sexually misidentified Matt (a character who accepts he is sexually undesirable but doesn?t let that define himself) would not get recognition for falling in love with the emotional succubus that is Mavis Gary (Charlize Theron). It?s easy to say Matt is naive in thinking Mavis won?t crush his soul after she seeks sexual comfort from the tiny chubster, but Matt is so much more than that. He is weak and strong, something a real person can identify with. He knows Mavis is a wretch of a human, and he sleeps with her not thinking it would make her fall in love with him, but maybe actually help him fall out of love with her. Unfortunately Young Adult is not Matt?s story to tell, and we are left uncertain as to Matt?s final outcome once he realizes Mavis has fled. It is obvious Oswalt was Matt at one point, and that makes his lack of nomination sting even more.

The ladies didn?t have it any easier this year, as two impressive women were left off the final list of Best Actress nominees. Both Tilda Swinton (We Need to Talk About Kevin) and Kirsten Dunst (Melancholia) submitted performances that were rooted in the evils or solace of sex. Both characters saw the adverse effects of their sexual decisions. Justine?s (Dunst) need for sex with a stranger the night of her wedding grants her a few fleeting moments of feeling something other than manic, but in the end she is living a sham of a life and wants others to accept their mortality on the cusp of the end of the world. Dunst?s performance is erotic in her unflinching bearing of herself, both physically and emotionally, yet it?s one of those performances where a beautiful person is not made ugly on the outside, but her overwhelming sadness destroys everyone watching. Dunst creates a character with such crippling melancholy that we cheer her on in ever poor decision she makes with her body.

Swinton?s Eva is a woman struggling to keep her unraveling marriage together as her terror of a son, Kevin (Ezra Miller), torments everyone from his younger sister and mother to his fellow students. Swinton is a chameleon, and she once again loses herself behind Eva?s perfectly manicured life. Hiding behind Swinton?s black eyes you can see the sadness of a woman whose sexual longing for her future husband Franklin (John C. Reilly) results in a real-life Damien, while she flashes back on how if she hadn?t given into her own desires her life wouldn?t been in the hellacious ditch it currently inhabits. Yes, Swinton already has an Oscar of her very own, but Eva is arguably one of the more underappreciated female characters of last year thanks to the film?s uncomfortable, ugly, and intense story; which is a shame of immeasurable proportions.

Ah! See what I did there? Shame? Yeah, okay you did. Shame is a film about a sex addict that almost feels like it needs less attention, and maybe in a way Fassbender?s Oscar snub is a direct result of championing a film too much. Fassbender bared not only his junk but also his character Brandon?s soul in Shame, completely immersing himself in a man whose sex appeal is actually his emotional undoing. Brandon could be anyone and have any addiction, but he is a rich white man with a little talked about addiction to carnal pleasures. He is sexy and disgusting, and Fassbender?s willingness to hold nothing back while in Brandon?s expensive shoes only proves that the Academy is afraid of sex for pleasure and wants to only reward actors engaging in sex on screen when the consequences are clear cut and easy to understand.

What other sexually proactive, engaging, or disturbing films and performances do you think the Academy failed to recognize this or in previous years?

Explore more on-screen sexuality

Source: http://www.rottentomatoes.com/m/1924383/news/1924383/

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Researchers discover method to unravel malaria's genetic secrets

Researchers discover method to unravel malaria's genetic secrets [ Back to EurekAlert! ] Public release date: 25-Jan-2012
[ | E-mail | Share Share ]

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health

The parasite that causes malaria is a genetic outlier, which has prevented scientists from discovering the functions of most of its genes. Researchers at National Jewish Health and Yale University School of Medicine have devised a technique to overcome the genetic oddity of Plasmodium falciparum, the major cause of human malaria. This new approach led them discover a new gene involved in lipid synthesis, and opens the door to further genetic discovery for the entire organism. This should foster a much greater understanding of the parasite, and facilitate discovery of new medications for a disease that infects more than 200 million people and kills nearly 700,000 every year.

"The malarial genome has been a black box. Our technique allows us to open that box, so that we can learn what genes in the most lethal human parasite actually do," said Dennis Voelker, PhD, Professor of Medicine at National Jewish Health and senior author on the paper that appeared in the January 2, 2012 , issue of the Journal of Biological Chemistry. "This could prove tremendously valuable in the fight against a disease that has become increasingly drug-resistant."

The genome of P. falciparum was sequenced in 2002, but the actual functions of many of the organism's genes have remained elusive. One of the primary methods for discovering gene function is to copy a specific gene, insert it into a model organism that is easy to grow, often the yeast Saccharomyces cerevisiae, then draw on the incredible knowledge base about yeast and its abundant genetic variants to discover how that inserted gene changes the organism's biology.

DNA is composed of building blocks with the shorthand designations A,T,C and G. The genome of P. falciparum is odd because it is particularly rich in A's and T's. Because of this A-T-rich nature, P. falciparum genes generally do not function when they are inserted into other organisms. As a result, scientists have been largely stymied when trying to understand the functions of P. falciparum's genes.

It turns out, however, that P. falciparum has a close cousin, P. knowlesi, which shares almost all its genes with P. falciparum, but with fewer A's and T's. As a result, P. knowlesi genes function well when inserted into yeast. Scientists can now insert P. knowlesi genes into yeast, discover their function, and then match them to corresponding genes in P. falciparum, which reveals the function of the malarial parasite's genes.

"This technique could lead to an explosion in knowledge about malaria and the parasite that causes it." said Dr. Voelker.

The researchers used the technique to discover a new gene involved in the synthesis of lipids in cell membranes of P. falciparum. The gene, phosphatidylserine decarboxylase, directs the formation of a protein unique to malarial parasites and is a potential therapeutic target. For example, selective disruption of lipid synthesis in P. falciparum, would prevent the organism from making new cell membranes, growing and reproducing in human hosts.

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Researchers discover method to unravel malaria's genetic secrets [ Back to EurekAlert! ] Public release date: 25-Jan-2012
[ | E-mail | Share Share ]

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health

The parasite that causes malaria is a genetic outlier, which has prevented scientists from discovering the functions of most of its genes. Researchers at National Jewish Health and Yale University School of Medicine have devised a technique to overcome the genetic oddity of Plasmodium falciparum, the major cause of human malaria. This new approach led them discover a new gene involved in lipid synthesis, and opens the door to further genetic discovery for the entire organism. This should foster a much greater understanding of the parasite, and facilitate discovery of new medications for a disease that infects more than 200 million people and kills nearly 700,000 every year.

"The malarial genome has been a black box. Our technique allows us to open that box, so that we can learn what genes in the most lethal human parasite actually do," said Dennis Voelker, PhD, Professor of Medicine at National Jewish Health and senior author on the paper that appeared in the January 2, 2012 , issue of the Journal of Biological Chemistry. "This could prove tremendously valuable in the fight against a disease that has become increasingly drug-resistant."

The genome of P. falciparum was sequenced in 2002, but the actual functions of many of the organism's genes have remained elusive. One of the primary methods for discovering gene function is to copy a specific gene, insert it into a model organism that is easy to grow, often the yeast Saccharomyces cerevisiae, then draw on the incredible knowledge base about yeast and its abundant genetic variants to discover how that inserted gene changes the organism's biology.

DNA is composed of building blocks with the shorthand designations A,T,C and G. The genome of P. falciparum is odd because it is particularly rich in A's and T's. Because of this A-T-rich nature, P. falciparum genes generally do not function when they are inserted into other organisms. As a result, scientists have been largely stymied when trying to understand the functions of P. falciparum's genes.

It turns out, however, that P. falciparum has a close cousin, P. knowlesi, which shares almost all its genes with P. falciparum, but with fewer A's and T's. As a result, P. knowlesi genes function well when inserted into yeast. Scientists can now insert P. knowlesi genes into yeast, discover their function, and then match them to corresponding genes in P. falciparum, which reveals the function of the malarial parasite's genes.

"This technique could lead to an explosion in knowledge about malaria and the parasite that causes it." said Dr. Voelker.

The researchers used the technique to discover a new gene involved in the synthesis of lipids in cell membranes of P. falciparum. The gene, phosphatidylserine decarboxylase, directs the formation of a protein unique to malarial parasites and is a potential therapeutic target. For example, selective disruption of lipid synthesis in P. falciparum, would prevent the organism from making new cell membranes, growing and reproducing in human hosts.

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Source: http://www.eurekalert.org/pub_releases/2012-01/njh-rdm012512.php

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Wednesday, January 25, 2012

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The custom-built "roleplay" system was designed and implemented by Eric Martindale as of July 2009. All attempts to replicate or otherwise emulate this system and its method of organizing roleplay are strictly prohibited without his express written and contractual permission; violators will be prosecuted to the fullest extent of the law.

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Cohabitating Valentines Are Happier Than Wedded Couples

ScienceDaily (Jan. 24, 2012) ? When it comes to the well-being of married versus cohabitating Valentines, wedded couples experience few advantages in psychological well-being and social ties, according to a new study at Cornell University.

The study, "Reexamining the Case for Marriage: Union Formation and Changes in Well-being," is being published in the February issue of the Journal of Marriage and Family.

"We found that differences between marriage and cohabitation tend to be small and dissipate after a honeymoon period. Also while married couples experienced health gains -- likely linked to the formal benefits of marriage such as shared health care plans -- cohabiting couples experienced greater gains in happiness and self-esteem. For some, cohabitation may come with fewer unwanted obligations than marriage and allow for more flexibility, autonomy and personal growth," said Kelly Musick, associate professor of policy analysis and management at Cornell's College of Human Ecology, who co-authored the study with sociologist Larry Bumpass of the University of Wisconsin-Madison.

"Marriage has long been an important social institution, but in recent decades western societies have experienced increases in cohabitation, before or instead of marriage, and increases in children born outside of marriage," said Musick. "These changes have blurred the boundaries of marriage, leading to questions about what difference marriage makes in comparison to alternatives."

Previous research has sought to prove a link between marriage and well-being, but many studies compared marriage to being single, or compared marriages and cohabitations at a single point in time.

This study compares marriage to cohabitation while using a fixed-effects approach that focuses on what changes occur when single men and women move into marriage or cohabitation and the extent to which any effects of marriage and cohabitation persist over time.

The researchers used a sample from the National Survey of Families and Households of 2,737 single men and women, 896 of whom married or moved in with a partner over the course of six years. The study focused on key areas of well-being, considering questions on happiness, levels of depression, health and social ties.

"Compared to most industrial countries, America continues to value marriage above other family forms," concluded Musick. "However our research shows that marriage is by no means unique in promoting well-being and that other forms of romantic relationships can provide many of the same benefits."

The study was funded in part by the National Institute of Child Health and Human Development and the Office of Behavioral and Social Sciences.

Contact Syl Kacapyr for information about Cornell's TV and radio studios.

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Journal Reference:

  1. Kelly Musick, Larry Bumpass. Reexamining the Case for Marriage: Union Formation and Changes in Well-being. Journal of Marriage and Family, 2012; 74 (1): 1 DOI: 10.1111/j.1741-3737.2011.00873.x

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/_fd5MWwJt3c/120124183755.htm

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Tuesday, January 24, 2012

US: Taliban must renounce terrorism for talks (AP)

KABUL, Afghanistan ? The Taliban must renounce ties to terrorists and endorse peace efforts as a condition for opening a political office in the Gulf state of Qatar, a senior U.S. diplomat said Sunday.

Marc Grossman, the special U.S. envoy to Afghanistan and Pakistan, called for quick work in setting up the office in Qatar, seen as a step to negotiating an end to the decade-long war in Afghanistan between the Taliban and the Western-backed government.

The issue underscores the complexity of efforts to wind down the war ahead of the scheduled departure of NATO combat forces by the end of 2014. Publicly, the Taliban have expressed no interest in reconciliation, and while the U.S. says repeatedly that the peace process must be led by Afghans, Kabul continues to fear it is being left out of the negotiating process.

Grossman spoke to reporters Sunday in Kabul alongside Afghanistan's Deputy Foreign Minister Jawed Ludin.

Grossman said Qatar and Afghanistan need to be in direct contact about the office, but "for an office to open, we also need to have a clear statement by the Afghan Taliban against international terrorism and in support of a peace process to end the armed conflict in Afghanistan."

Grossman, speaking at the Afghan Foreign Ministry on a snowy evening in Kabul, noted that the Afghan government would welcome a delegation from Qatar to discuss setting up the office.

Reassuring Afghan President Hamid Karzai, who fears he is being sidelined by U.S. efforts to find a political resolution to the war, Grossman said, "Only Afghans can decide the future of Afghanistan."

Before making his first visit to Afghanistan, Grossman made stops in Turkey, Saudi Arabia, the United Arab Emirates and India. He wanted to stop in Pakistan as well, but he said Pakistani officials did not want to meet with him now because they were still revising their policy toward the U.S.

The relationship is badly strained over the U.S. unilateral raid in Pakistan that killed al-Qaida leader Osama bin Laden and a U.S. airstrike late last year that killed 24 Pakistan soldiers. Pakistan, where many Afghan insurgent leaders are said to be based, has closed overland routes into Afghanistan for U.S. and NATO war supplies.

Both Grossman and Ludin said Pakistan has a crucial role to play in efforts to craft a peace deal with the Taliban.

"There really can't be a comprehensive settlement here ? a peace process ? unless Pakistan is part of it," Grossman said.

Last year Washington opened secret negotiations with the Taliban exploring their willingness to enter into peace talks ahead of the withdrawal of U.S. troops.

Talks with the Taliban briefly faltered last summer after Karzai learned of the clandestine negotiations and made them public, temporarily scuttling them. Privately, Karzai has expressed fears that the United States will broker a deal with the Taliban that will be imposed on his government.

U.S. conversations with Taliban representatives have focused on establishing the Taliban office in Qatar and prisoner exchanges. The Taliban are seeking the release of five prisoners from the U.S. military prison in Guantanamo Bay, Cuba, including Khairullah Khairkhwa, the former governor of Herat province, and Mullah Mohammed Fasl, a top Taliban commander.

Ludin expressed the Afghan government's support in getting a Taliban political office opened in Qatar and said it also would back an American decision to transfer some Taliban detainees from the U.S. military prison in Guantanamo Bay, Cuba, to Qatar.

"If the United States decides to transfer these detainees to Qatar, to the extent that that means that these people will be reunited with their families, the Afghan government will support it. ... but you also will have to ascertain the desire of the detainees themselves," Ludin said.

Grossman said no decision has been made about the transferring detainees from Guantanamo Bay.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20120122/ap_on_re_as/as_afghan_talks

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Gaddafi supporters seize control of Libyan town (Reuters)

TRIPOLI (Reuters) ? Supporters of ousted Libyan leader Muammar Gaddafi seized control of the town of Bani Walid on Monday after clashes with a militia loyal to the new government in which four people were killed, witnesses told Reuters.

A resident of Bani Walid, about 200 km (120 miles) south-east of Tripoli, said the sides fought using heavy weaponry, including 106 mm anti-tank weapons, and that 20 people were wounded.

Another witness told Reuters the fighting had now stopped but that Gaddafi loyalists were in control of the town centre, where they were flying green flags, a symbol of allegiance to the ousted administration.

"They control the town now. They are roaming the town," said the witness, a fighter with the 28th May militia which was fighting the Gaddafi loyalists.

Bani Walid, base of the powerful Warfallah tribe, was one of the last towns in Libya to surrender to the anti-Gaddafi rebellion last year. Many people there oppose the country's new leadership.

The uprising in Bani Walid could not come at a worse time for the ruling National Transitional Council (NTC). It is already reeling from violent protests in the eastern city of Benghazi and the resignation of its second most senior official.

An air force official told Reuters that jets were being mobilized to fly to Bani Walid. In Tripoli, there were signs of security being tightened, Reuters reporters in the city said.

FIGHTERS "MASSACRED"

The violence in Bani Walid was sparked when members of the May 28 militia arrested some Gaddafi loyalists.

That prompted other supporters of the former leader, who was captured and killed in October, to attack the militia's garrison in the town, said the resident, who spoke on condition of anonymity.

"They massacred men at the doors of the militia headquarters," said the resident.

During Libya's nine-month civil war, anti-Gaddafi rebels fought for months to take Bani Walid.

Local tribal elders eventually agreed to let NTC fighters enter the town, but relations have been uneasy since and there have been occasional flare-ups of violence.

In November last year, several people were killed in Bani Walid when a militia group from Tripoli's Souq al-Juma district arrived in the town to try to arrest some local men.

Taking back control of the town will be challenging because it has natural defenses. Anyone approaching from the north has to descend into a deep valley and then climb up the other side, giving defenders an advantage.

It was this landscape, in part, that prevented anti-Gaddafi militias from taking the town during the civil war, despite the fact they were heavily armed and had superior numbers.

(Writing by Christian Lowe; Editing by Myra MacDonald)

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/nm/20120123/wl_nm/us_libya_fighting

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Monday, January 23, 2012

Derailed by Cancer at the Height of the Recession (ContributorNetwork)

With one year to go before the 2012 general election and on the heels of October's jobless report, Yahoo! News asked readers and contributors to share their personal employment stories. Below is one perspective.

FIRST PERSON | In late 2006, I was a busy massage therapist working in a hospital for a program I had helped start. Between my 32-hour week at the hospital, my private clients, and some child support, I had a decent income for a single mom in San Mateo, Calif.

I had excellent health care benefits, without which I am sure I would not be alive today. My income was right around the median of $60,000 a year. Supporting my two children on this was tight in this expensive part of the world, but we managed.

In early 2007, I was diagnosed with Stage IIIC Inflammatory Breast Cancer and knocked abruptly out of the working world. The next 14 months were devoted to fighting for my life. I had aggressive treatment, and my oncologist did not want me exposed to the germs my clients would bring me. Fortunately, I was immediately qualified for disability, evidently because I was not expected to live.

In early 2008, I jubilantly rejoined the work force, cancer-free, just as the recession was gathering momentum. The massage department shut down. I had to have health insurance because I knew I was at high risk for recurrence and no private insurer would cover me. I became a secretary for another department, and the long hours at the computer were disastrous. I developed lymphedema in my left arm, which caused it to ache and swell. In August of 2009, that department shut down. My disability resumed, and the hospital's insurer, MetLife, supplied the difference between what Social Security Disability paid and two-thirds of my previous income.

I haven't had even a half-time job since.

Now, in 2011, I have patched together a work life of several jobs that allows me to work within my limitations. With the current national unemployment rate at 9 percent, I am just happy to work at all. When I lost my secretarial job, my fiance and I moved up our wedding date and I was able to get health insurance. I shudder to think of what could have happened to me otherwise, if my cancer had come back! MetLife decided after two years that my memory problems (chemo-brain) and gimpy left arm allowed me to work as a file clerk for 40 hours per week, and informed me two weeks after they sent their last check. They declined to clarify where I could actually find this job.

I currently provide massage therapy to children at Lucille Packard Children's Hospital for about 20 hours a month. I teach theater arts to children. I visit elderly people with mild dementia and keep them engaged. I blog and advocate for the end of breast cancer. I see the occasional private client and elevate my arm afterward. I earn about one-third of what I earned before. I hope that 2012 will open doors to more hours, more jobs, or both.

My husband is still supporting his own children, so our combined income is barely sufficient. We are fed, clothed and sheltered, but braces for my teenagers will have to wait.

This Saturday I celebrate my 50th birthday and I'm still here. For now that's enough.

Source: http://us.rd.yahoo.com/dailynews/rss/cancer/*http%3A//news.yahoo.com/s/ac/20120120/hl_ac/10364659_derailed_by_cancer_at_the_height_of_the_recession

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