Sunday, March 31, 2013

Business, labor get deal on worker program

WASHINGTON (AP) -- Big business and labor have struck a deal on a new low-skilled worker program, removing the biggest hurdle to completion of sweeping immigration legislation allowing 11 million illegal immigrants eventual U.S. citizenship, labor and Senate officials said Saturday.

The agreement was reached in a phone call late Friday night with AFL-CIO President Richard Trumka, U.S. Chamber of Commerce head Tom Donohue, and Democratic Sen. Chuck Schumer of New York, who's been mediating the dispute.

The deal resolves disagreements over wages for the new workers and which industries would be included. Those disputes had led talks to break down a week ago, throwing into doubt whether Schumer and seven other senators crafting a comprehensive bipartisan immigration bill would be able to complete their work as planned.

The deal must still be signed off on by the other senators working with Schumer, including Republicans John McCain of Arizona and Marco Rubio of Florida, but that's expected to happen, according to a person with knowledge of the talks who spoke on condition of anonymity. With the agreement in place, the senators are expected to unveil their legislation the week of April 8. Their measure would secure the border, crack down on employers, improve legal immigration and create a 13-year pathway to citizenship for the millions of illegal immigrants already here.

It's a major second-term priority of President Barack Obama's and would usher in the most dramatic changes to the nation's faltering immigration system in more than two decades.

"The strength of the consensus across America for just reform has afforded us the momentum needed to forge an agreement in principle to develop a new type of employer visa system," Trumka said in a statement late Saturday. "We expect that this new program, which benefits not just business, but everyone, will promote long overdue reforms by raising the bar for existing programs."

Schumer said: "This issue has always been the dealbreaker on immigration reform, but not this time."

The AFL-CIO and the Chamber of Commerce, longtime antagonists over temporary worker programs, had been fighting over wages for tens of thousands of low-skilled workers who would be brought in under the new program to fill jobs in construction, hotels and resorts, nursing homes and restaurants, and other industries.

Under the agreement, a new "W'' visa program would go into effect beginning April 1, 2015, according to an AFL-CIO fact sheet.

In year one of the program, 20,000 workers would be allowed in; in year two, 35,000; in year three, 55,000; and in year four, 75,000. Ultimately the program would be capped at 200,000 workers a year, but the number of visas would fluctuate, depending on unemployment rates, job openings, employer demand and data collected by a new federal bureau pushed by the labor movement as an objective monitor of the market. One-third of all visas in any year would go to businesses with under 25 workers.

A "safety valve" would allow employers to exceed the cap if they can show need and pay premium wages, but any additional workers brought in would be subtracted from the following year's cap.

The workers could move from employer to employer and would be able to petition for permanent residency after a year, and ultimately seek U.S. citizenship. Neither is possible for temporary workers now.

The new program would fill needs employers say they have that are not currently met by U.S. immigration programs. Most industries don't have a good way to hire a steady supply of foreign workers because there's one temporary visa program for low-wage nonagricultural workers but it's capped at 66,000 visas per year and is only supposed to be used for seasonal or temporary jobs.

Business has sought temporary worker programs in a quest for a cheaper workforce, but labor has opposed the programs because of concerns over working conditions and the effect on jobs and wages for U.S. workers. The issue helped sink the last major attempt at immigration overhaul in 2007, which the AFL-CIO opposed partly because of temporary worker provisions, and the flare-up earlier this month sparked concerns that the same thing would happen this time around. Agreement between the two traditional foes is one of many indications that immigration reform has its best chance in years in Congress this year.

After apparent miscommunications earlier this month between the AFL-CIO and the Chamber of Commerce on the wage issue, the deal resolves it in a way both sides are comfortable with, officials said.

Workers would earn actual wages paid to American workers or the prevailing wages for the industry they're working in, whichever is higher. The Labor Department would determine prevailing wage based on customary rates in specific localities, so that it would vary from city to city.

There also had been disagreement on how to handle the construction industry, which unions argue is different from other industries in the new program because it can be more seasonal in nature and includes a number of higher-skilled trades. The official said the resolution will cap at 15,000 a year the number of visas that can be sought by the construction industry.

Schumer called White House chief of staff Denis McDonough on Saturday to inform him of the deal, the person with knowledge of the talks said. The three principals in the talks ? Trumka, Donohue and Schumer ? agreed they should meet for dinner soon to celebrate, the person said.

However, in a sign of the delicate and uncertain negotiations still ahead, Rubio sent a letter Saturday to Judiciary Committee Chairman Patrick Leahy, D-Vt., calling for a deliberate hearing process on the new legislation and cautioning against a "rush to legislate." Rubio and a number of other Republicans are striking a tricky balance as they simultaneously court conservative and Hispanic voters on the immigration issue.

Separately, the new immigration bill also is expected to offer many more visas for high-tech workers, new visas for agriculture workers, and provisions allowing some agriculture workers already in the U.S. a speedier path to citizenship than that provided to other illegal immigrants, in an effort to create a stable agricultural workforce.

___

Follow Erica Werner on Twitter: https://twitter.com/ericawerner

Source: http://news.yahoo.com/business-labor-deal-worker-program-004139778.html

natalie wood patriots Sandy Hook Hoax 2014 Corvette Stacie Halas Corvette Stingray Claire Danes

North Korea says enters "state of war" against South

By Jack Kim

SEOUL (Reuters) - North Korea said on Saturday it was entering a "state of war" with South Korea, its latest bout of angry rhetoric directed at Seoul and Washington, but the South brushed off the statement as little more than tough talk.

The North also threatened to shut down an industrial zone it operates jointly with the South near the heavily armed border between the two sides if Seoul continued to say the complex was being kept running for money.

The two Koreas have been technically in a state of war for six decades under a truce that ended their 1950-53 conflict. Despite its threats, few people see any indication Pyongyang will risk a near-certain defeat by re-starting full-scale war.

"From this time on, the North-South relations will be entering the state of war and all issues raised between the North and the South will be handled accordingly," a statement carried by the North's official KCNA news agency said.

KCNA said the statement was issued jointly by the North's government, ruling party and other organizations.

There was no sign of unusual activity in the North's military to suggest an imminent aggression, a South Korean defense ministry official said.

The North has been threatening to attack the South and U.S. military bases almost on a daily basis since the beginning of March, when U.S. and South Korean militaries started routine drills that have been conducted for decades without incident.

Many in the South have regarded the North's willingness to keep open the Kaesong industrial zone, located just a few miles (km) north of the border, as a sign that Pyongyang will not risk losing a lucrative source of foreign currency by mounting a real act of aggression.

The Kaesong zone is a vital source of hard currency for the impoverished state and hundreds of South Korean workers and vehicles enter daily after crossing the armed border.

"If the puppet traitor group continues to mention the Kaesong industrial zone is being kept operating and damages our dignity, it will be mercilessly shut off and shut down," KCNA quoted an agency that operates Kaesong as saying in a statement.

The threat to shut it down could sharply escalate tensions because it would suspend a symbolic joint project run by the rivals. It could also trap hundreds of South Korean workers and managers of the 123 firms that have factories there.

The North has previously suspended operations at the factory zone at the height of political tensions with the South, only to let it resume operations later.

The project has been kept running despite the North's move on Wednesday to cut off a military hotline used to process the hundreds of workers and vehicles that cross the Demilitarized Zone border.

"We have been exercising extreme restraint considering the plight of medium and small companies whose livelihood depends on the Kaesong industrial project as an immediate shutdown will drive them to bankruptcy and people jobless," KCNA quoted the agency as saying.

The South's Unification Ministry, which handles political ties with the North, said earlier in the day that the Kaesong industrial park was operating as normal with workers and vehicles crossing the border both says.

"North Korea's statement today (on entering a state of war) ... is not a new threat but is the continuation of provocative threats," a ministry statement said.

North Korean leader Kim Jong-un on Friday signed off on an order putting its missile units on standby to attack U.S. military bases in the South and the Pacific, after the United States flew two nuclear-capable stealth bombers over the Korean peninsula in a rare show of force.

U.S. officials said the B-2 bombers were on a diplomatic sortie aimed at reassuring allies South Korea and Japan and were also aimed at trying to nudge Pyongyang back to dialogue, although there was no guarantee Kim would get the message as intended.

The South Korean government brushed off the North's latest statement on entering a state of war, saying there was nothing fresh in it to cause greater alarm. South Koreans went about with daily lives as they have done through March under the North's constant threat of attack.

(Additional reporting by Sung-won Shim and Jane Chung; Editing by Raju Gopalakrishnan)

Source: http://news.yahoo.com/north-korea-says-enter-state-war-against-south-001304441.html

strikeforce tate vs rousey strawberry festival knicks the monkees ciaa love actually strikeforce

CA-BUSINESS Summary

Record Wall Street boosts sentiment, U.S. holds key in Q2

TOKYO (Reuters) - Whether the world's largest economy can sustain momentum will be a primary focus for investors for the next three months after a general recovery trend in the United States helped risk sentiment for broad markets in the first quarter of 2013. Asian shares edged higher and the euro steadied on Friday after banks in Cyprus reopened to relative calm. Overall trade was subdued, with many Asian markets, including Australia, Singapore and Hong Kong, closed on Friday for Easter holidays.

Banks lift TSX on Cyprus calm; index up for quarter

TORONTO (Reuters) - Canada's main stock index powered ahead in a late surge on Thursday, led by strength in financial and industrial shares, on relief that banks in Cyprus reopened relatively smoothly following a bailout deal. The market received further support from BlackBerry after the smartphone maker reported a surprise quarterly profit.

More trouble for Cohen's SAC Capital as Steinberg indicted in NY

(Reuters) - U.S. prosecutors on Friday charged Michael Steinberg, a veteran portfolio manager at Steven A. Cohen's hedge fund, with insider trading in two technology stocks, the most senior SAC Capital Advisors' employee to be indicted in the government's long-running probe. FBI agents arrested Steinberg at his Park Avenue home in New York City at around 6 a.m. EDT (1000 GMT). Steinberg, wearing a blue sweater, pleaded "not guilty" to charges of securities fraud and conspiracy to commit securities when he appeared at a late morning arraignment.

Chesapeake names Dixon interim CEO as McClendon set to leave

(Reuters) - Chesapeake Energy Corp appointed Chief Operating Officer Steven Dixon as interim chief executive officer on Friday and made him part of a three-person committee to search for a replacement for Aubrey McClendon. McClendon is expected to step down on Monday.

Monte Paschi says lost billions in deposits after Feb scandal

MILAN (Reuters) - Customers' deposits at Italian bank Monte dei Paschi fell by "a few billion euros" after a scandal erupted in February over loss-making derivatives trades at the lender, the bank said in a document posted on its web site on Saturday. Monte dei Paschi last week reported a higher-than-expected net loss for the whole of 2012 on the back of a rise in provisions for bad loans and 730 million euros in losses on the derivatives trades, which are at the center of a fraud.

Loeb's Third Point outperforms hedge fund rivals again

BOSTON (Reuters) - Hedge fund manager Daniel Loeb outperformed his rivals again in the first quarter with returns that kept pace with the stock market's recent rally, a person familiar with Loeb's returns said. The New York-based manager told investors late on Thursday that his flagship Third Point Offshore Fund rose 2.8 percent in March while the Third Point Ultra fund, the leveraged version of the Offshore fund, gained 4.2 percent.

Cyprus details heavy losses for major bank customers

NICOSIA (Reuters) - Major depositors in Cyprus's biggest bank will lose around 60 percent of savings over 100,000 euros, its central bank confirmed on Saturday, sharpening the terms of a bailout that has shaken European banks but saved the island from bankruptcy. Initial signs that big depositors in Bank of Cyprus would take a hit of 30 to 40 percent - the first time the euro zone has made bank customers contribute to a bailout - had already unnerved investors in European lenders this week.

EU, IMF resisting merger of Greek banks NBG, Eurobank: paper

ATHENS (Reuters) - Greece's international lenders have asked Athens to halt the merger of National Bank with Eurobank , worried that the resulting lender would be too big for the state to deal with, daily Kathimerini reported on Saturday. The paper said the European Union, European Central Bank and International Monetary Fund troika had raised issues over the size of the merged entity relative to Greece's gross domestic product (GDP) and the banking sector as a whole.

Areva CEO says would be interested in Urenco stake: paper

PARIS (Reuters) - French nuclear group Areva would be interested in taking a stake in uranium enrichment firm Urenco, Areva's CEO was quoted as saying on Saturday. Urenco, owned by the British and Dutch states and Germany's two top utilities, is up for sale and Areva - which already has a partnership with Urenco - is believed to be a leading contender to buy a stake in the firm. Areva so far had played down its possible interest in Urenco.

Exclusive: Indonesia's CT Corp proposes all-cash deal for Bakrie's media unit

TANJUNG BENOA, Indonesia (Reuters) - Indonesia's fifth-richest man has proposed to buy a controlling stake in PT Visi Media Asia, valued at up to $1.8 billion, in an all-cash deal that would give him the lion's share of the TV advertising market in Southeast Asia's biggest economy. Chairul Tanjung, the billionaire founder and chairman of CT Corp, a conglomerate with banking and media interests, told Reuters that his company wanted to buy the stake in the media unit of Indonesia's powerful Bakrie family without any partners.

Source: http://news.yahoo.com/ca-business-summary-012952632--finance.html

kansas jayhawks mega millions results louisville lotto numbers susan powell megamillions winners university of louisville

Saturday, March 30, 2013

Good results Using These Home Improvement Suggestions ...

If you?ve reviewed home improvement, you understand how difficult it might be to consider a large task. Thankfully, this collection of tips will be here to help you! After looking at this article, you may be a lot more prepared to begin modifying your property in the property of your own goals.

Should your property was integrated the seventies or before, odds are very good which it was designed with only a extremely slim covering of insulation during the entire whole framework. Essentially, the covering ought to be around 27 centimeters or 10.5 in . thick. By increasing the density of insulation on the recommended four to six in ., you could potentially very easily conserve a couple of one hundred dollars a year.

If you?d prefer to enhance your property but can?t afford to pay for a redesign look at changing your lighting fixtures. You?ve almost certainly discovered regions that want better lighting, so, this is the time to handle that issue. There are numerous designs from which to choose. Be imaginative and go for a brand new appear. Reduce up all those dim regions at home and switch out all those out dated variations with the addition of new lighting fixtures.

Be sure you consider both before and after images of any function or upgrades you need to do to your property. You could possibly prefer to look back on all of the perseverance and modifications when it seems like the task in general will not be completed. Keep photographs on your personal computer or keep these things printed out for any scrapbook.

Plant your backyard during the summer if you have the room on your lawn. This can help you save money on household goods and it is a great add-on for your personal friends for taking a gander at in case you are having a outdoor area get together during the summer time. It is a fun loved ones activity.

Design and style your suitable home online. There are numerous of room organizing computer software equipment that will assist you to make the ideal layout for your personal home. It is possible to pull and decrease the units and kitchen appliances into your room plan. Remember to abandon no less than 36? to 48? of floor space in front of kitchen appliances and kitchen cabinets, as you need to be capable of available the doors pleasantly. After you have the optimal layout figured out, it will be much easier to acquire exactly what you need.

A fantastic home improvement idea for selling your own home as well as enhancing the way appears would be to put exterior lighting. Whether or not you?re lighting the front yard or perhaps your entrance and rear deck, some exterior lighting on and around your own home will make a significant difference and makes it possible for your own home to face out.

Minimal home improvement function may be taken care of from the homeowner with no need to require a service provider. Simply by making minor repairs and upgrades a property owner can improve the price of his or her property by way of a unexpected sum. Relying on the homeowners personal capabilities can make renovations more affordable, as there is no profit eliminate for extraneous installers and experts.

It?s important to offer the correct information just before wanting to deal with a residence development project. Should you mess up, it could possibly really set you back. Now, nevertheless, you possess lots of information about how to succeed at changing your own home for your needs. Quickly enough, it will be easy to sense happy with your newly-renovated residence.

Source: http://footballmanaged.org/good-results-using-these-home-improvement-suggestions/

ron paul nevada buffalo chicken dip super bowl 2012 soul train nevada caucus ufc 143 what time does the super bowl start

PST: Ex-French star calls Beckham 'unprofessional'

At this point, if we don?t all know what Brand Beckham is all about, then the joke is on us.

Apparently, former France international Bixente Lizarazu was not paying attention over the last few years as David Beckham frequently treated the LA Galaxy as his little side gig, clearly second fiddle to building and maintaining the iconic brand.

Lizarazu ? if the guy is still in soccer, I can?t find evidence of it ? found someone interested in what he has to say. So he took the opportunity to beat on Beckham a little for jet-setting over to China before next week?s huge Champions League clash; Beckham?s Paris Saint-Germain faces Barcelona in the marquee UEFA semifinal.

What Lizarazu told TF1:

I am sorry, but travelling to China to promote football only 10 days before the most important game of the season is simply not the right way to prepare. No other club would allow one of their players to go on a trip like this. It?s unprofessional.?

Uh, well, actually we know that one club did exactly that. The Galaxy generally acquiesced when Beckham wanted to go to his next royal wedding, modeling gig, Olympic event, etc.

PSG manager Carlo Ancelotti, by the way, wasn?t too worked up about it. He said Beckham returned on Wednesday and missed just one training session.

Source: http://prosoccertalk.nbcsports.com/2013/03/29/former-french-international-calls-david-beckham-unprofessional/related/

paulina gretzky david bowie elvis presley elvis presley Pretty Little Liars Rob Parker Comcast

Exeter brain cancer sufferer defies diagnosis to stage festival this ...

FINAL preparations are being made for a mini festival organised by a woman to celebrate defying the medical prognosis of her ?inoperable? brain tumour.

Two years ago Gemma Wensley, of St Leonard?s was preparing her own funeral after being told her cancer was terminal. She was given just months to live.

But after baffling medical staff with her recovery from an inoperable tumour in her brain stem, the 31-year-old from St Leonard?s in Exeter is now looking forward to her own festival that she has organised with the help of her close friend Susan Luscombe.

Gem Fest is taking place at the Exeter Phoenix on Sunday, March 31.

Replacement boilers suplied and fitted from ?1195+vat

Simon Turner

View details

Print voucher

Replacement boilers suplied and fitted from ?1195+vat

Contact: 01395 200611

Valid until: Tuesday, April 30 2013

The day will be divided into two sections. It begins with a free family-orientated day between noon and 5pm, with activities including arts and crafts, story-telling, stalls, a cinema, face painting and various games and competitions. There is a small charge for some activities.

The second part of the day takes place between 6pm and 2am and costs ?12 a ticket. This will feature two music stages with both local and national performers. There is also a lounge upstairs which will be converted into an acoustic stage, a DJ set in the terrace and comedy in the black box.

Gemma said: ?Meeting for planning and making final arrangements for day and evening events has all gone extremely well, everyone has been on board from the get go and been massively helpful.

?I can't believe that we are so close to the big day and nerves are kicking in now.

?We never envisaged that our first Gemfest would evolve into such a big event, everyone involved has shown such generosity it has taken on a life of its own.

?Posters and flyers should be visible all around the city and we just hope that everyone comes along to enjoy it with us and all our hard work pays off so we can raise some serious cash and awareness for a great charity."

Money raised will be donated to brain cancer charities.

To make a donation visit www.just giving.com/Gemfestexeter

Source: http://www.thisisexeter.co.uk/Exeter-brain-cancer-sufferer-defies-diagnosis/story-18556176-detail/story.html

Nathan Adrian London 2012 Synchronized Swimming London 2012 hurdles Taylor Kinney Beach Volleyball Olympics 2012 Jessica Ennis Aliya Mustafina

BofA markets chief was bank's highest paid executive in '12

By Rick Rothacker

(Reuters) - Bank of America Corp's co-chief operating officer, Tom Montag, was once again the bank's highest paid executive in 2012, making $14.5 million in a year in which the bank showed signs of healing.

Montag's compensation, which included a $5.46 million bonus and $8.19 million in stock, increased 21 percent to eclipse the $12 million awarded to Chief Executive Brian Moynihan, according to a filing the bank made on Thursday with the U.S. Securities and Exchange Commission.

Bank of America's executives were handed bigger pay packages in 2012 as the No. 2 U.S. bank by assets made progress in recovering from the 2007-2009 financial crisis. Its shares climbed more than 100 percent in 2012, while the bank padded its capital holdings and made strides in resolving mortgage-related litigation.

In his annual letter to shareholders, which was posted on the bank's website on Thursday, Moynihan struck an optimistic tone, saying the company had been "transformed" by a stronger balance sheet and a focus on core customers.

The letter also signaled Moynihan's plans for rewarding shareholders by buying back more stock. Earlier this month, the bank passed the Federal Reserve's annual stress test and won permission to repurchase $5 billion of its own shares.

"We are well-positioned to return excess capital to our shareholders and we believe that buying back common shares is the best way to continue to drive value for our shareholders," Moynihan wrote.

As part of this year's stress test, the bank did not request an increase in its quarterly dividend, which has been stuck at a penny per share since the financial crisis.

Moynihan, whose compensation was disclosed last month, was the bank's second-highest-paid executive after his total rose more than 70 percent to $12 million thanks to a higher stock grant of $11.1 million. He did not receive a cash bonus.

Montag, who runs global banking and markets businesses, has made more money than the CEO since joining Bank of America through its 2009 acquisition of Merrill Lynch & Co. In 2012, he also earned more than the CEOs at JPMorgan Chase & Co and Morgan Stanley .

Bank of America Chief Financial Officer Bruce Thompson made $11 million, followed by co-Chief Operating Officer David Darnell ($9.5 million) and general counsel Gary Lynch ($7 million), according to the filing.

For 2013, the bank is increasing Moynihan's salary by 58 percent to $1.5 million and upping the base pay for Montag and Darnell by 18 percent to $1 million.

BOARD SHAKE-UP

Thursday's proxy filing also disclosed that five of the bank's 18 directors will not stand for election at this spring's shareholder meeting as part of a board shuffle that began last summer.

Three directors who were at or near the retirement age of 72 - Virgis Colbert, Donald Powell and Charles Rossotti - are departing, joining two other directors - Robert Scully and Mukesh Ambani - who had previously announced they were leaving.

The exits are the latest reshaping of the bank's board, which will shrink to 13 members.

In 2009, federal regulators pressed the bank to add directors with more financial expertise after the company required multiple bailouts during the financial crisis. Of those six board members, only former Federal Reserve Governor Susan Bies and former DuPont

CEO Chad Holliday remain.

In anticipation of retirements, the bank has added six new board members since August, all of whom will stand for election at the May 8 shareholder meeting. Four of the new directors were found through a search firm and two others were identified by Holliday, the board's chairman, according to the filing.

(Reporting by Rick Rothacker in Charlotte, N.C.; Editing by Steve Orlofsky, Bernard Orr)

Source: http://news.yahoo.com/bofa-markets-chief-banks-highest-paid-executive-12-180240240--sector.html

academy award winners best picture 2012 oscar winners channel 3 news j lo j lo sacha baron cohen ryan seacrest

New vaccine-design approach targets viruses such as HIV

Mar. 28, 2013 ? A team led by scientists from The Scripps Research Institute (TSRI) and the International AIDS Vaccine Initiative (IAVI) has unveiled a new technique for vaccine design that could be particularly useful against HIV and other fast-changing viruses.

The report, which appears March 28, 2013, in Science Express, the early online edition of the journal Science, offers a step toward solving what has been one of the central problems of modern vaccine design: how to stimulate the immune system to produce the right kind of antibody response to protect against a wide range of viral strains. The researchers demonstrated their new technique by engineering an immunogen (substance that induces immunity) that has promise to reliably initiate an otherwise rare response effective against many types of HIV.

"We're hoping to test this immunogen soon in mice engineered to produce human antibodies, and eventually in humans," said team leader William R. Schief, who is an associate professor of immunology and member of the IAVI Neutralizing Antibody Center at TSRI.

Seeking a Better Way

For highly variable viruses such as HIV and influenza, vaccine researchers want to elicit antibodies that protect against most or all viral strains -- not just a few strains, as seasonal flu vaccines currently on the market. Vaccine researchers have identified several of these broadly neutralizing antibodies from long-term HIV-positive survivors, harvesting antibody-producing B cells from blood samples and then sifting through them to identify those that produce antibodies capable of neutralizing multiple strains of HIV. Such broadly neutralizing antibodies typically work by blocking crucial functional sites on a virus that are conserved among different strains despite high mutation elsewhere.

However, even with these powerful broadly neutralizing antibodies in hand, scientists need to find a way to elicit their production in the body through a vaccine. "For example, to elicit broadly neutralizing antibodies called VRC01-class antibodies that neutralize 90 percent of known HIV strains, you could try using the HIV envelope protein as your immunogen," said Schief, "but you run into the problem that the envelope protein doesn't bind with any detectable affinity to the B cells needed to launch a broadly neutralizing antibody response."

To reliably initiate that VRC01-class antibody response, Schief and his colleagues therefore sought to develop a new method for designing vaccine immunogens.

From Weak to Strong

Joseph Jardine, a TSRI graduate student in the Schief laboratory, evaluated the genes of VRC01-producing B cells in order to deduce the identities of the less mature B cells -- known as germline B cells -- from which they originate. Germline B cells are major targets of modern viral vaccines, because it is the initial stimulation of these B cells and their antibodies that leads to a long-term antibody response.

In response to vaccination, germline B cells could, in principle, mature into the desired VRC01-producing B cells -- but natural HIV proteins fail to bind or stimulate these germline B cells so they cannot get the process started. The team thus set out to design an artificial immunogen that would be successful at achieving this.

Jardine used a protein modeling software suite called Rosetta to improve the binding of VRC01 germline B cell antibodies to HIV's envelope protein. "We asked Rosetta to look for mutations on the side of the HIV envelope protein that would help it bind tightly to our germline antibodies," he said.

Rosetta identified dozens of mutations that could help improve binding to germline antibodies. Jardine then generated libraries that contained all possible combinations of beneficial mutations, resulting in millions of mutants, and screened them using techniques called yeast surface display and FACS. This combination of computational prediction and directed evolution successfully produced a few mutant envelope proteins with high affinity for germline VRC01-class antibodies.

Jardine then focused on making a minimal immunogen -- much smaller than HIV envelope -- and so continued development using the "engineered outer domain (eOD)" previously developed by Po-Ssu Huang in the Schief lab while Schief was at the University of Washington. Several iterative rounds of design and selection using a panel of germline antibodies produced a final, optimized immunogen -- a construct they called eOD-GT6.

A Closer Look

To get a better look at eOD-GT6 and its interaction with germline antibodies, the team turned to the laboratory of Ian A. Wilson, chair of the Department of Integrative Structural and Computational Biology and a member of the IAVI Neutralizing Antibody Center at TSRI.

Jean-Philippe Julien, a senior research associate in the Wilson laboratory, determined the 3D atomic structure of the designed immunogen using X-ray crystallography -- and, in an unusual feat, also determined the crystal structure of a germline VRC01 antibody, plus the structure of the immunogen and antibody bound together.

"We wanted to know whether eOD-GT6 looked the way we anticipated and whether it bound to the antibody in the way that we predicted -- and in both cases the answer was 'yes'," said Julien. "We also were able to identify the key mutations that conferred its reactivity with germline VRC01 antibodies."

Mimicking a Virus

Vaccine researchers know that such an immunogen typically does better at stimulating an antibody response when it is presented not as a single copy but in a closely spaced cluster of multiple copies, and with only its antibody-binding end exposed. "We wanted it to look like a virus," said Sergey Menis, a visiting graduate student in the Schief laboratory.

Menis therefore devised a tiny virus-mimicking particle made from 60 copies of an obscure bacterial enzyme and coated it with 60 copies of eOD-GT6. The particle worked well at activating VRC01 germline B cells and even mature B cells in the lab dish, whereas single-copy eOD-GT6 did not.

"Essentially it's a self-assembling nanoparticle that presents the immunogen in a properly oriented way," Menis said. "We're hoping that this approach can be used not just for an HIV vaccine but for many other vaccines, too."

The next step for the eOD-GT6 immunogen project, said Schief, is to test its ability to stimulate an antibody response in lab animals that are themselves engineered to produce human germline antibodies. The difficulty with testing immunogens that target human germline antibodies is that animals typically used for vaccine testing cannot make those same antibodies. So the team is collaborating with other researchers who are engineering mice to produce human germline antibodies. After that, he hopes to learn how to drive the response, from the activation of the germline B cells all the way to the production of mature, broadly neutralizing VRC01-class antibodies, using a series of designed immunogens.

Schief also hopes they will be able to test their germline-targeting approach in humans sooner rather than later, noting "it will be really important to find out if this works in a human being."

The first authors of the paper, "Rational HIV immunogen design to target specific germline B cell receptors," were Jardine, Julien and Menis. Co-authors were Takayuki Ota and Devin Sok of the Nemazee and Burton laboratories at TSRI, respectively; Travis Nieusma of the Ward laboratory at TSRI; John Mathison of the Ulevitch laboratory at TSRI; Oleksandr Kalyuzhniy and Skye MacPherson, researchers in the Schief laboratory from IAVI and TSRI, respectively; Po-Ssu Huang and David Baker of the University of Washington, Seattle; Andrew McGuire and Leonidas Stamatatos of the Seattle Biomedical Research Institute; and TSRI principal investigators Andrew B. Ward, David Nemazee, Ian A. Wilson, and Dennis R. Burton, who is also head of the IAVI Neutralizing Center at TSRI.

The project was funded in part by IAVI; the National Institutes of Health (AI84817, AI081625 and AI33292); and the Ragon Institute.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Scripps Research Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Joseph Jardine, Jean-Philippe Julien, Sergey Menis, Takayuki Ota, Oleksandr Kalyuzhniy, Andrew McGuire, Devin Sok, Po-Ssu Huang, Skye MacPherson, Meaghan Jones, Travis Nieusma, John Mathison, David Baker, Andrew B. Ward, Dennis R. Burton, Leonidas Stamatatos, David Nemazee, Ian A. Wilson, and William R. Schief. Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors. Science, 28 March 2013 DOI: 10.1126/science.1234150

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/72Dc77mGmGc/130328161421.htm

san francisco earthquake san francisco earthquake terminator salvation terminator salvation deron williams jarhead montrose

Friday, March 29, 2013

Marriage debate revives questions about high court role as social change-maker

By Tom Curry, National Affairs Writer, NBC News

Underneath all the arcane legal fencing in this week?s Supreme Court oral arguments on marriage lies a basic question: Why should the justices take on the job of redefining marriage laws for the nation?

Is it the best venue for making decisions that could fundamentally change social institutions such as marriage? Is it the courts, in the person of unelected life-tenured justices? Or is it the democratic process in the states and in Congress?

The Supreme Court appeared ready to strike down the Defense of Marriage Act during Wednesday's oral arguments but it was a different story for Prop. 8 with Justices signaling that they may take a narrow approach to avoid setting a national precedent on the issue of same-sex marriage. California Attorney General Kamala Harris discusses.

At least some elected officials, including President Barack Obama and many Democratic members of Congress are saying to the high court: ?You decide this.?

Even some Democratic members of Congress, such as Sen. Patrick Leahy of Vermont, who voted for the 1996 Defense of Marriage Act (DOMA)?defining marriage as ?a legal union between one man and one woman as husband and wife,? told the high court in their amicus brief that they?d made a big mistake in 1996 -- and now they want the justices to fix it.

But at least some of the justices are pushing back and saying to the politicians: ?Why don?t you decide this??

Justice Samuel Alito said to Solicitor General Donald Verrilli?on Tuesday as Verrilli?was urging the court to strike down California's traditional marriage definition: ?You want us to step in and render a decision based on an assessment of the effects of this institution which is newer than cellphones or the Internet??

Alito said that he and his fellow justices ?do not have the ability to see the future,? implying that they shouldn?t be the lawmakers for American society.

This week North Dakota became the latest state to challenge Roe v. Wade ? moving to ban abortion as early as six weeks into pregnancy. On the heels of Arkansas and other states chipping away at abortion access, those caught up in the debate think abortion could soon be headed back to the Supreme Court. Planned Parenthood president Cecile Richards discusses.

The court does have experience in overriding decisions made by the people and their elected representatives and spurring fundamental social change ? for example, the Brown v. Board of Education decision that ordered an end to racial segregation in public schools in 1954 and the 1973 Roe v. Wade ruling that legalized most abortions nationwide.

Whether the court wants the job of social change-maker on marriage remains to be seen.

It may hinge on Justice Anthony Kennedy?s view of Section 3 of DOMA. If Kennedy and his colleagues strike down Section 3, then, as Verrilli said, it is ?difficult? to see how laws in the 38 states that define marriage almost exactly as Section 3 does would survive court challenges.

Both Charles Cooper, the lawyer defending California?s traditional marriage law before the court on Tuesday, and Paul Clement on Wednesday defending section 3 of DOMA, pleaded with the justices to let the democratic process work.

?Persuasion,? Clement said in his closing argument. ?That's what the democratic process requires. You have to persuade somebody you're right? That's going on across the country. Colorado, the state that brought you Amendment 2 (which essentially banned gay rights in the state in 1992), has just recognized civil unions. Maine, that was pointed to in the record in this case as being evidence of the persistence of discrimination because they voted down a statewide (same-sex) referendum, the next election cycle it came out the other way.?

Clement implied that the political momentum is all in the direction of gay and lesbian rights.

But he omitted mention of North Carolina, which last May became the thirtieth state in the union to amend its constitution to prohibit same-sex marriages. Three out of five North Carolina voters voted for the amendment.

Chief Justice Roberts also seemed to making a case for the court staying out of the fray, implying that gays and lesbians are powerful enough to get politicians? attention.

In an allusion to recent same-sex marriage endorsements by politicians such as Sen. Kay Hagan, D-N.C., and Sen. Rob Portman, R-Ohio, Roberts told lawyer Roberta Kaplan -- representing Edith Windsor, who is seeking to have DOMA overturned -- that ?political figures are falling over themselves to endorse your side of the case.?

He told Kaplan that ?the political force and effectiveness of people representing, supporting your side of the case? had led to laws being changed in nine states to allow same-sex couples to marry.

He asked ?You don't doubt that the lobby supporting the enactment of same sex-marriage laws in different states is politically powerful, do you??

Chip Somodevilla / Getty Images

George Washington University students and hundreds of others rally outside the Supreme Court during oral arguments in a case challenging the Defense of Marriage Act (DOMA) March 27, 2013 in Washington, DC.

Kaplan disagreed. Her argument and the Obama administration?s rests partly on a contention that gays and lesbians are a politically powerless minority.

In his brief, Verrilli?wrote that ?the final consideration is whether gays and lesbian people are ?a minority or politically powerless.? They are both.? If gays are powerless and are what the courts call ?a suspect class,? then?it is easier to strike down laws that affect them under Supreme Court precedents.

Evidence that gays and lesbians aren?t powerless is that politicians such as Hagan, who is up for re-election next year in a state that just banned same-sex marriages, are now not shy about joining the same-sex marriage cause.

But to say it?s no longer too politically risky for Hagan in North Carolina to endorse the right of same-sex couples to marry is not the same as saying there are now the votes in North Carolina to rescind the marriage law which voters enacted just last year.

Putting national polls aside for the moment, it may be useful to look at the pattern of voting in states where real, flesh-and-blood voters have recently voted on marriage.

Maryland voters last November approved a referendum that allows gay and lesbian couples to marry. The vote was 52.4 percent to 47.6 percent ? this is in a state that Obama carried with 62 percent.

The pattern reflected the long-standing urban/rural split in politics; urban and suburban counties such as Montgomery County, in the suburbs of Washington, D.C., approved the measure. Two-thirds of Montgomery County voters voted for it.

But in rural counties such as Harford County, the measure was defeated. It was also narrowly defeated in predominantly African-American Prince George?s County in the Washington suburbs.?

The pattern in the state of Washington, where voters last November approved a measure legalizing same-sex marriage, was the same. In suburban Snohomish County, 53 percent of voters voted for legal recognition of same-sex marriages; just across the mountains in rural Chelan County, 57 percent of voters rejected same-sex marriages.

Many of the 38 states that have traditional marriage laws have conservative electorates that more closely resemble rural counties' electorates than urban ones.?It may be, as Clement argued, that momentum will eventually move people in those 38 states to OK same-sex marriages, or it may be that Kennedy and his colleagues won?t wait, and will decide the question for them.

Related:

Supreme Court likely to advance gay marriage but stop short of broad ruling

Shifts on same-sex marriage come from surprising groups

Obama on rights of gay couples: 'It is time for the justices to examine this issue'

This story was originally published on

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2a202663/l/0Lnbcpolitics0Bnbcnews0N0C0Inews0C20A130C0A30C290C1750A50A910Emarriage0Edebate0Erevives0Equestions0Eabout0Ehigh0Ecourt0Erole0Eas0Esocial0Echange0Emaker0Dlite/story01.htm

elon musk fox mole manson bubba watson recent earthquakes fbi most wanted list stuttering

Thursday, March 28, 2013

Ford not 'yet' ready to talk 'Star Wars' sequels

This 1977 publicity photo provided by 20th Century-Fox Film Corporation shows, from left, Harrison Ford, Carrie Fisher, and Mark Hamill in a scene from the film, "Star Wars," released by 20th Century-Fox. (AP Photo/20th Century-Fox Film Corporation)

This 1977 publicity photo provided by 20th Century-Fox Film Corporation shows, from left, Harrison Ford, Carrie Fisher, and Mark Hamill in a scene from the film, "Star Wars," released by 20th Century-Fox. (AP Photo/20th Century-Fox Film Corporation)

LOS ANGELES (AP) ? Harrison Ford isn't ready ? "yet" ? to talk about his reported part in Disney's planned "Star Wars" sequel, but he praises its director, J.J. Abrams.

"I think he's fantastic," Ford said in a recent interview. "I did his first movie, 'Regarding Henry,' with Mike Nichols. A wonderful talent. Extraordinary guy."

The 70-year-old actor ? who came to fame playing Han Solo in the "Star Wars" trilogy ? is shrugging off questions about that character while promoting his role as Brooklyn Dodgers president Branch Rickey in the upcoming Jackie Robinson film "42."

Asked how he feels generally that the "Star Wars" sequel and Disney spinoffs are in the works, Ford responded: "I don't feel anything at the moment yet."

In an article published earlier this month, "Star Wars" creator George Lucas told Bloomberg Businessweek that Ford, Mark Hamill and Carrie Fisher had been in negotiations to return to the franchise even before Lucasfilm was sold to Disney last fall.

Was Ford surprised by that announcement? He makes the universal zipping-my-lips sign. Asked what it will take to get him to commit to play Han Solo again, Ford said, "Um, I don't even want to discuss that. It's great. Ain't it great?"

It's been over two decades since Abrams wrote the "Regarding Henry" screenplay. Have the two chatted recently?

"About what?" Ford asked, smirking and taking a slow sip from a cup.

____

Follow Ryan Pearson at http://www.twitter.com/ryanwrd

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-03-27-People-Ford/id-a279cc89f94d43e1b361d712909188ae

holes ncaa brackets 2012 odd lamar d antoni fashion star andrew bird

Toddler Mauled by 7 Dogs Dies in Georgia | WebProNews

Family pets are,on the internet at least, normally shown as protective of their family, especially babies and children. One family in Georgia, however, learned that some pets don?t make friends with toddlers.

Local Savannah, Georgia news station WTOC is reporting that a 21-month-old girl was killed when seven dogs attacked her outside her home in Ellabell, Georgia. The seven dogs were all pit bulls or pit bull-mixed, and have now been put down.

The girl, Monica Laminack, reportedly crawled outside through a doggie door while her 12-year-old brother was supposed to be watching her. In total, there were a reported five people in the house at the time of the mauling. The family owned a total of nine dogs. A beagle and Irish setter were not involved in the attack, and were not put down.

Bryan County Sheriff Clyde Smith told WTOC that the girl was found with multiple bites on her body and had apparently been dragged throughout the yard sometime during the hour-and-a-half after she crawled outside. Smith related that the girl?s body was cold when first responders arrived, indicating that she had been dead for some time. The sheriff indicated that he expects charges related to the death to be filed.

(Image courtesy Dante Alighieri/Wikimedia Commons)

Source: http://www.webpronews.com/toddler-mauled-by-7-dogs-dies-in-georgia-2013-03

Revolution TV Show bankofamerica rosh hashanah rosh hashanah boardwalk empire iOS 6 Release Date Canelo Alvarez

BlackBerry makes $94 million on revenue of $2.7 billion, ships 1 million BB10 devices in 2013 Q4

Image

This isn't quite the BlackBerry earnings story you're waiting for -- after all, the US figures covering the success (or otherwise) of the Z10 won't arrive until the next quarter. Instead, we're looking at the company's results from the end of the fiscal year to March 2nd, which shows that the smartphone maker made $94 million in GAAP income on revenues of $2.7 billion -- in contrast with the $125 million net loss it made in the same quarter last year. More importantly, however, it shipped out almost one million BlackBerry 10 devices during the three weeks of the quarter that they were available. In addition, it managed to push five million of its older smartphones and 370,000 PlayBook tablets out of the door, but saw user numbers fall from 79 million last quarter to 76 million now.

As revenue has remained relatively flat, the surge in profits can only be attributed to Thorsten Heins' aggressive cost-cutting measures, with the CEO remarking that the "numerous changes" he has implemented at the company have "resulted in [BlackBerry] returning to profitability." At the same time, Mike Lazaridis has announced that he'll retire from his position as vice-chair and director of the outfit he founded the better part of three decades ago. He'll exit the business on May 1st so that he can concentrate on his new enterprise, Quantum Valley Investments.

Update: During the conference call, Thorsten Heins has revealed that around two-thirds or three-quarters of the one million BB10 devices shipped have been sold.

Filed under: , ,

Comments

Source: ADVFN

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Wg-vQaU-DRI/

ozzie guillen fidel castro darvish george zimmerman website edmund fitzgerald uss enterprise white house easter egg roll 2012 andy cohen

Use a Plastic Bag and the Camera You Already Have to Create Cool, Vintage-Style Photos

Use a Plastic Bag and the Camera You Already Have to Create Cool, Vintage-Style PhotosWe're all familiar with vintage-style camera effects thanks to popular apps like Instagram, but applying those modifications after you take the image doesn't look as authentic and can hurt the image quality. Instead, you can create true light leaks and special effect color with a plastic sandwich bag and a colored marker. DIY Photography explains:

Take two plastic sandwitch bagies, color one with a marker some bright color like pink or purple and leave the other clear.

On the opposite end as the zip-lock (the closed end) rip it, tear it or cut it in some uneven fashion so that it is now open on both ends.

Wrap the zip-lock end around your camera lens leaving the torn end overlapping the lens a little bit. Most of us are holding the lens while we shoot so now you are holding the plastic bag on the lens with your hand.

Now manipulate the bag as you shoot so the center of the lens is unobstructed and have fun!

The image above demonstrates how this all should look when you're done, plus one sample photo created with this nifty DIY trick. To see more awesome examples, check out the full post over at DIY Photography.

Pro-Tip: Make Cool Hazy/Light Leak/Mystical Photos With A Sandwich Baggie And A Colored Marker | DIY Photography

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/3C6A3o0Z1_U/use-a-plastic-bag-and-the-camera-you-already-have-to-create-cool-vintage+style-photos

printable bracket game change own stacy francis tournament brackets 2012 ncaa basketball tournament walt

Rhode Island city drops fine for allegedly foul-mouthed cockatoo

Mar 26 (Reuters) - Leading money winners on the 2013 PGATour on Monday (U.S. unless stated): 1. Tiger Woods $3,787,600 2. Brandt Snedeker $2,859,920 3. Matt Kuchar $2,154,500 4. Steve Stricker $1,820,000 5. Phil Mickelson $1,650,260 6. Hunter Mahan $1,553,965 7. John Merrick $1,343,514 8. Dustin Johnson $1,330,507 9. Russell Henley $1,313,280 10. Kevin Streelman $1,310,343 11. Keegan Bradley $1,274,593 12. Charles Howell III $1,256,373 13. Michael Thompson $1,254,669 14. Brian Gay $1,171,721 15. Justin Rose $1,155,550 16. Jason Day $1,115,565 17. Chris Kirk $1,097,053 18. ...

Source: http://news.yahoo.com/rhode-island-city-drops-fine-allegedly-foul-mouthed-160315662.html

nick santino bruce arians the misfits hook troy miracle andy whitfield

Wednesday, March 27, 2013

PFT: Browns announce signing of QB Campbell

Andrus+Veerpalu+Men+15KM+Free+Event+FIS+Nordic+d65c8_K8S1VxGetty Images

The 2011 labor agreement included an important provision:? HGH testing is coming to the NFL.? Nearly 20 months later, HGH testing is no closer than it was before the agreement was signed.

The latest evidence comes from the case of Andrus Veerpalu, an Estonian skier whose three-year suspension was overturned by the Court of Arbitration for Sport.? Naturally, the NFL and the NFLPA disagree as to the meaning of the ruling, and the incident has caused Albert Breer of NFL Network to learn that the two sides have scrapped an agreement to conduct a so-called ?population study? aimed at gauging the permissible natural levels of HGH in football players.

The details don?t matter, because neither the NFL nor Congress is willing to do anything more than huff and puff about the union?s refusal to honor the agreement to submit to HGH testing.? As a result, the perception is that neither the NFLPA nor the NFL truly want HGH testing.

Since the day the NFL banned the use of HGH, the prohibition has been enforced via the honor system.? The problem with the honor system? ? It works roughly as well as the rhythm method.? So with no way to test for HGH, players will get caught only if a vial of HGH falls out of their letterman jackets, or if the player?s name pops up in the records of an HGH supplier the government is prosecuting.

Surely, the NFL and the NFLPA realize that, if/when HGH testing begins, plenty of players will be caught.? Which will reduce the supply of healthy players.? In turn, players who quit using HGH will not recover as quickly from injuries, likewise reducing the supply of healthy players.

And it won?t be good for the game if players are busted for using HGH, even though most fans presume that they?re using something to get big, to stay big, and/or to rebound from big hits applied by other big men.

If the NFL truly wanted to force the issue on HGH testing, wouldn?t the league unleash the legal hounds and push the issue in court or via an arbitration?? The players already have agreed to submit to testing, and the NFL has more than enough ammunition to argue that the NFLPA deliberately is dragging its feet.? The idea that the NFL doesn?t want to force players to the needle by court order only goes so far.? At some point, the NFL needs to do more than complain about the NFLPA?s refusal to proceed, or the NFLPA will continue to refuse to proceed.

Likewise, Congress has proven to be impotent on the topic, periodically issuing hollow threats but never taking action.

Through it all, the delay has given those who use HGH an opportunity to find better masking agents ? or to develop the next wave of substances that work like HGH but for which testing doesn?t yet exist.

The best news for the NFL, the NFLPA, and Congress is that neither the media nor the fans seem to care that the NFL and the NFLPA have struck a deal to abandon the honor system, but that the honor system has continued to be used for two seasons, and counting.

Source: http://profootballtalk.nbcsports.com/2013/03/26/browns-announce-acquisition-of-jason-campbell/related/

yu darvish mad cow pennsylvania primary jerome simpson hand sanitizer obama on jimmy fallon google drive

Dell XPS 13-MLK


The Dell XPS 13-MLK ($1,399) is an ultrabook built for travel, with a strong, compact chassis made with exotic materials. It has most of the high-end features that power users look for, including a high-performance Core i5 processor, a sizable solid-state drive (SSD), and a comfortable full-size keyboard. Physically, it's a match for those 11-inch laptops that you've got your eye on, but the 13-inch screen is much larger. A couple of omissions keep it from our highest honors, but if you're willing to overlook those stumbles, the XPS 13 makes for a road warrior's dream machine.

Design and Features
The XPS 13 is svelte, with an aluminum, Gorilla Glass, and carbon fiber composite construction that feels sturdy. It measures about 0.71 by 12.5 by 8 inches (HWD) and weighs 2.96 pounds (without the AC adapter), making the XPS 13 a skoch larger and heavier than the Apple MacBook Air 11-inch (Mid 2012) ($999), but measurably smaller and lighter than our current Editors' Choice for high-end ultrabooks, the 13-inch Asus Zenbook Prime Touch UX31A-BHI5T ($1,199). This makes the XPS 13 as portable and compact as the 11-inch class of laptops, a plus if you're a road warrior with an already overloaded travel bag.

It's also a boon if you regularly compute on an airline tray table, as the extra inch of depth can mean the difference between using the screen tilted back or tilted forward if the person in front of you suddenly reclines his seat. Unfortunately, the XPS 13 doesn't have a touch screen, which would add some thickness and probably some depth to the system. While the system's trackpad is very responsive and works well with Windows 8 gestures, we still found ourselves trying to tap elements on the system's screen.

In addition to the new Intel Core i5-3337U processor with Intel HD Graphics 4000, the XPS 13's newsworthy feature is the system's new 1,920-by-1,080-resolution 13-inch screen. This is an improvement over the 1,366-by-768 screen in the 2012 version of the Dell XPS 13 ($1,000). The screen is bright and has a good range of brightness settings so you can use the system in both dim and daylight-lit environments. Speaking of dim light, the system's backlit chiclet-style keyboard was both visible and very comfortable to use, with contoured keys and good key placement. Boot up and waking the system from sleep was quick, thanks to the system's 256GB SSD. The drive has a very good 186GB of 221GB free on the C: drive when you take it out of the box. The recovery partition, the OS, and the pre-installed programs occupy the rest of the SSD.

Because of its compact chassis, the XPS 13 doesn't have too much room for extraneous I/O ports. Therefore, it is no surprise that the XPS 13 only has a pair of USB 3.0 ports and a mini-DisplayPort in addition to the headset jack. The USB 3.0 ports are black, instead of the more traditional blue-colored ports. Thankfully, the system doesn't have any USB 2.0 ports that could be confused for the faster USB 3.0 ports. The mini-DisplayPort is the only video port, so you'll need an adapter to use the system with DVI, VGA, or HDMI. The only other features on the side bezels are the system's AC adapter jack and a nice push-button controlled row of LEDs to let you know the system's battery status. The system comes with a sealed 47WHr battery, par for the compact ultrabook category. If you want a removable battery, you'll have to buy a larger laptop.

The system comes with a few pre-installed apps, including Kindle, Amazon, Getting Started with Windows 8, McAfee Security Center, Skype, Dell Shop, Dell Support Center, Microsoft Office Trial, and Absolute Data Protect. These apps are in addition to the usual Windows 8 apps that come with every system, like the Windows Store, music player, Bing News, and photo viewer. All in all, this isn't a bad selection of pre-installed apps, especially compared with systems with a plethora of pre-installed apps like games from the Xbox store.

Performance
Dell XPS 13-MLK The XPS 13's Intel Core i5-3337U processor, Intel HD Graphics 4000, 8GB of DDR3 memory, and a speedy 256GB SSD puts it in a statistical dead heat with other systems with similar specs like the Vizio 14-Inch Thin + Light (CT14-A4) ($849) and even systems with faster processors like the Core i7-equipped HP Spectre XT TouchSmart Ultrabook 15-4010nr ($1,340). With these midrange Intel Core processors, Intel integrated graphics, and SSD or SSD+HDD storage, each system is equally proficient at multimedia tasks like Handbrake and Photoshop CS6, day-to-day tasks (PCMark 7), and at light 3D gaming. Essentially, the current crop of performance ultrabooks have the chops to do most general tasks asked by their users.

If the XPS 13 has any failings in the performance department, it's that the system's hungry 1080p display and slim sealed battery are only good for a moderate five hours (4:56) on our battery rundown test. While that score is better than the Vizio CT14-A4 (4:30) and HP Spectre XT (4:03), all these battery times are woefully short of the 6:38 that the Asus Zenbook UX31A-BHI5T scored.

The Dell XPS 13-MLK is a good fit for the road warrior who wants to carry some multimedia horsepower with her. Its 1080p screen, capacious SSD, and Core i5 power will go a long way if you need to rework a complex PowerPoint presentation or work on some photos for a pitch on the road. They're also good components for the travelling artist, especially if you're already used to carrying your work on an external USB 3.0 drive. The things holding the XPS 13 back from our highest honors are the lack of a touch screen and a lower battery life than the current high-end ultrabook Editor's Choice, the Asus Zenbook Prime Touch UX31A-BHI5T. Thanks to a better bang for the buck and that touch screen, the Asus UX31A-BHI5T holds on to its ultrabook crown.

BENCHMARK TEST RESULTS

COMPARISON TABLE
Compare the Dell XPS 13-MLK with several other laptops side by side.

More laptop reviews:
??? Dell Inspiron 17-3721
??? Dell XPS 13-MLK
??? MSI GX60 1AC-021US
??? Acer Aspire M5-581T-6405
??? Acer Aspire M5-481PT-6644
?? more

laptop

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/U-aO5NOHVh8/0,2817,2417029,00.asp

sag awards red carpet torrey pines nhl all star game 2012 pollyanna samuel adams snowy owl one for the money

Tuesday, March 26, 2013

Bearing up in Glendale: Another bruin takes to the city

Just as the memory of "Meatball," Glendale's favorite bear, may be fading, it appears a new bruin has taken to the city.

And this black bear ? described as 3 to 4 feet tall and weighing about 200 pounds ? has a fondness for hummingbird sugar water and a taste for honey. This dietary insight is based on its snacking habits during multiple visits over the course of at least six months to the Chevy Chase Canyon neighborhood.

In some cases, the bear has knocked down hummingbird feeders hanging as high as 8 feet off the ground.

"I was kind of surprised another bear is back," said resident Suzanne Whitman, whose bird feeder was knocked down about 4:30 a.m. Tuesday at her home on Chevy Chase Drive. The bear, she said, visited her home twice last year.

The bear may also be responsible for destroying Herbert Harder's small backyard apiary, which contained seven beehives that he had maintained for 30 years. Harder hasn't replaced the hives and isn't entirely sure he wants to take the risk.

It took only three visits for the bear to decimate Harder's honey crop and population of bees, he said. But the bear's fourth visit was the most devastating, since it tore apart several hives and sent others rolling down a steep hillside.

Harder's hummingbird feeders also found themselves on the bear's menu.

According to residents, the bear visited the Chevy Chase Canyon neighborhood at least seven times last year, including a foray into a trash bin for chicken, rice and baklava.

Other trash runs, door-pawing and sunbathing sightings have prompted police responses, including a helicopter search and the use of air horns and floodlights.

After spending winter in their dens, bears typically leave their hide-outs around spring and begin foraging for food, said Kevin Brennan, a biologist with the California Department of Fish and Wildlife.

A bear usually starts feeding on grass, but an urban bear may yearn for something a little tastier ? and fattier.

Human garbage, Brennan said, is higher in protein fat than a bear's natural diet, making the human food irresistible.

"Bears are smart animals and they go back to those sources," Brennan said.

With a very acute sense of smell, bears will go virtually anywhere and put up with almost anything to reach a source of tasty food, he said.

Though state wildlife officials were aware of a bear's past visits to the Chevy Chase Canyon area, they had not received any recent reports, Brennan said. Still, he added, "they are creatures of habit."

Harder said he wants the bear to be trapped and relocated just like Meatball, who was moved earlier this year to an animal sanctuary in San Diego County after twice being relocated deep within Angeles National Forest.

"He is going to stay here until he destroys everything or hurts someone," Harder said.

The gender of the bear has yet to be verified.

But trapping and relocating doesn't work, Brennan said, noting Meatball's persistence.

"The issue is not the bears. The issue is improper storage of garbage," he said.

Whitman, a neighborhood watch block captain, has urged neighbors to cover their trash bins and to keep small children and animals inside at night.

In her 25 years of living in the canyon, she said she has never before had visits from a bear.

"It's a little too much nature," Whitman said.

veronica.rocha@latimes.com

Source: http://feeds.latimes.com/~r/latimes/news/science/~3/_Ubre5bxhcg/la-me-bear-back-20130325,0,82661.story

London 2012 Table Tennis badminton Dominique Dawes Gabby Olympic Gymnast Robyn Lawley Gore Vidal mlb trade rumors

Viewers to choose ending of 'Psych' 100th episode

This publicity image released by USA Network shows Dule Hill as Gus Guster, left, and James Roday as Shawn Spencer in a scene from the 100th episode of "Psych," airing Wednesday, March 27 on USA. The network plans to let viewers of "Psych" choose the ending of Wednesday's episode, both a celebration of the drama's 100th episode and culmination of a two-year experiment at an exclusively fan-centered approach at marketing. (AP Photo/USA Network, Alan Zenuk)

This publicity image released by USA Network shows Dule Hill as Gus Guster, left, and James Roday as Shawn Spencer in a scene from the 100th episode of "Psych," airing Wednesday, March 27 on USA. The network plans to let viewers of "Psych" choose the ending of Wednesday's episode, both a celebration of the drama's 100th episode and culmination of a two-year experiment at an exclusively fan-centered approach at marketing. (AP Photo/USA Network, Alan Zenuk)

(AP) ? From a bank of chairs in an NBC Universal control room, technician Antonella Caruso counted down as if she were anticipating a rocket booster's liftoff: "Nine, eight, seven, six ..."

It was a dress rehearsal for USA's plan to let viewers of "Psych" choose the ending of Wednesday's episode, celebrating the drama's 100th episode and culminating the network's two-year experiment at an exclusively fan-centered approach at marketing.

In the episode, Shawn (actor James Roday) and Gus (Dule Hill) try to solve a murder at a party hosted by an old rock star in a California mansion. There are five suspects: the groupie, the manager, the author, the host and, of course, the butler. During the show, the suspects are narrowed down to three and viewers are asked to vote on social media who they thought committed the crime. Three endings were filmed, each lasting three minutes, and the top vote-getter will be used.

The episode salutes the 1985 film "Clue" and features that film's actors Christopher Lloyd, Lesley Ann Warren and Martin Mull, along with guest shots from Garrett Morris and Curt Smith of Tears For Fears.

Depending on where you live, you could see a different ending. USA is conducting separate votes for the East and West coast airings of the show. (Viewers in other time zones will see the Eastern version at 10 p.m. Eastern.) They estimate tabulating 190,000 to 250,000 votes.

Viewer-selected endings aren't necessarily unique (CBS' "Hawaii Five-0" did one this year), but here fans will be updated a handful of times during the show on how the vote is going. That's where Caruso's practice came in; she was counting down to an insert of a vote tally.

"Psych" is in its seventh season, a point at which most shows are considered "mature" and are losing viewers, but it does have a relatively young, devoted audience and is USA's third most-popular original show behind "Burn Notice" and "Suits." Instead of running general advertisements encouraging viewership when its sixth season started last year, USA sought to engage fans through social media and activities, said Alexandra Shapiro, USA's executive vice president of marketing and digital.

"It's great to be loved," Shapiro said. "But you have to love back."

USA set up online games for "Psych" fans to play, with real and virtual prizes. Particularly high-scoring fans even become part of the game. There was a fan appreciation day, with some invited to meet the cast. USA encouraged social media interaction with stars and others involved with the show. A "slumber party" of viewer-chosen shows that aired from midnight to 6 a.m. on a Saturday in February resulted in some 157,000 mentions on Twitter.

One goal is to make live viewing of new episodes an event, Shapiro said. DVR viewing is fine, but networks still reliably make more money when there is a strong audience for original airings.

So far, so good. The February debut of the seventh season saw stronger ratings than the sixth season opener in 2012, with a 22 percent increase in the desirable young audience of viewers aged 18-to-34, the Nielsen company said.

"Our job is so much harder than it was 10 years ago or even five years ago," Shapiro said. "We used to be content messengers. Now you have to be content creators. You as a marketer have to create compelling content that a fan is going to engage with."

It's not necessarily an approach that works with every show, she said. But it could be a template for some with similar audiences.

For this week, the chief concern is compiling the fans' votes, and making sure technicians in New Jersey charged with making sure the correct ending of Wednesday's episode is inserted.

___

EDITOR'S NOTE ? David Bauder can be reached at dbauder(at)ap.org or on Twitter (at)dbauder.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-03-26-TV-Psych%20Ending/id-f70a322a709f4932acef90955d9fd9b9

19 kids and counting danny o brien alicia silverstone park slope food coop anchorman sequel safety not guaranteed lifehouse